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[1] Geier, D. A., et al (2007), A Review of Thimerosal (Merthiolate) and its Ethilmercury breakdown Product: Specific Historical Considerations Regarding Safety and Effectiveness, Journal of Toxicology and Environmental Health, Part B: Critical Reviews, 10:8, 575-596.

 

[2] Menick, J. G., et al (2008), Molecular Structures of Thimerosal (Merthiolate) and Other Arylthiolate Mercury Alkyl Compounds, Inorg. Chem., 47, 6421-6426.

 

[3] Pubchem, http://pubchem.ncbi.nlm.nih.gov/compound/thimerosal, acedido a 20.05.2015.

 

[4] Dórea, J. G., et al (2013), Toxicity of Ethylmercury (and Thimerosal): a Comparison with Methylmercury, J. Appl. Toxicol. 2013; 33: 700–711.

 

[5] Wu, C., et al (2008), Thiol-Modulated Mechanisms of the Cytotoxicity of Thimerosal and Inhibition of DNA Topoisomerase IIα, Chem. Res. Toxicol., 21, 483–493.

 

[6] Curtis Klaassen, Casarett & Doull’s Toxicology The Basic Science of Poisons, Mc Graw Hill Lange, 7th edition, 2008. 

 

[7] Picichero, M. et al (2002), Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study, Lancet, 360,1737-1741.

 

[8] Burbacher, T.M. et al (2005), Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methyl mercury or Vaccines Containing Thimerosal. Environmental Health Perspectives. National Institutes of Environmental Health Sciences, 113(8): 1015–1021.

 

[9] WHO, http://www.who.int/vaccine_safety/committee/topics/thiomersal/questions/en/, acedido a 21.05.2015

 

[10] EMA, http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500015546.pdf,acedido a 22.05.2015

 

[11] Clements, C. J. and P. B. McIntyre (2006). When science is not enough-a risk/benefit profile of thiomersal-containing vaccines. Expert Opin Drug Saf.;5(1):17-29.

 

[12] Hooker B., Kern J.,Geier D., Haley B., Sykes L., King P., Geier M. (2014), Methodological issues and evidence of malfeasance in research purponting  to show  thimerosalin vaccines is safe, BiomedResearch International, 247218.

 

[13] Geier D, King P, Hooker B, Dórea J, Kern J, Sykes L, Geier M. (2015), “Thimerosal: Clinical, epidemiologic and biochemical studies”, (2015) Clinica Chimica Acta Volume 444, Pages 212–220

 

[14] Hornig M, Chian D, Lipkin WI (2005), Neurotoxic effects of postnatal thimerosal are mouse strain dependent,Molecular Psychiatry, 9, 833–845

 

[15] Xiaoling L, et al (2014), Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal, Toxicological Sciences, 139(2), 452–465

 

[16] Clements C, McIntyre P. (2006), When science is not enough – a risk/benefit profile of thiomersal-containing vaccines, Ashley Publications ISSN 1474-0338

 

 

 

Bibliografia de imagens:

 

[a] http://upload.wikimedia.org/wikipedia/commons/7/7d/Thiomersal-from-xtal-3D-balls.png

 

[b] https://theunaustraliandotnet.files.wordpress.com/2015/01/vaccine121014.jpg

 

[c] http://youtu.be/mLHnUjhzv9E

 

[d] http://www.vaccinationnews.org/DailyNews/2004/February/02_11_04.htm

 

[e] http://www.ct.gov/despp/lib/despp/dss/lab_hist_3.jpg

 

[f] http://www.studiekeuzeid.nl/studies/?isat=34899#

 

[g]http://www.preciolandia.com/br/ratos-de-laboratorio-mecol-twister-7h0439-a.html

 

[h] http://br.freepik.com/fotos-vetores-gratis/sinal-de-perigo

 

[i] http://www.hailhailmedia.com/x-marks-the-spot/

 

[j] http://it.wikipedia.org/wiki/Controversie_sul_Thimerosal

 

[l] http://www.merckmillipore.com/INTL/es/product/Timerosal,MDA_CHEM-817043

 

[m] Dórea, J. G., et al (2013), Toxicity of Ethylmercury (and Thimerosal): a Comparison with Methylmercury, J. Appl. Toxicol. 2013; 33: 700–711.

 

[n] Wu, X., et al. (2008),Thiol-modulated mechanisms of the cytotoxicity of thimerosal and inhibition of DNA topoisomerase IIα, Chemical research in toxicology 21(2): 483-493, 

 

[o] http://bellcitycrossfit.com/wp-content/uploads/2014/04/Spinal-Cordandbrain_updated.jpg

 

[p] http://www.adammichalski.pl/wp-content/uploads/2014/11/profilaktyka-nerek.jpg

 

[q] Adaptado de Casarett & Doull’s, Toxicology, The Basic Science of Poisons, Mc Graw Hill Lange, 7th edition, 2008, 

 

[r] http://www.noticiasnaturais.com/2009/08/panavax-a-vacina-da-sanofi-para-o-brasil-e-com-mercurio/

 

[s] http://parapais.com/search/bebe-queicho-pequeno-com-lingua-pra-fora/

 

[t] http://www.flaticon.com/free-icon/question-mark_36601

 

[u] http://healthimpactnews.com/2014/cdc-responds-admits-omitting-vaccine-data-linking-vaccines-to-higher-rates-of-autism/

 

[v] http://www.a12.com/noticias/detalhes/oms-22-milhoes-de-criancas-nao-receberam-vacinas-para-prevenir-doencas

 

[x] http://www.ulficlinica.pt/images/dgs_logogrande.jpg

 

[z] http://www.chm.bris.ac.uk/motm/thiomersal/thiomersalh.htm

 

 

 

 

 

 

 

Encontre-nos

© 2015 por Faculdade de Farmácia da Universidade do Porto

Endereço

Faculdade de Farmácia da Universidade do Porto 
Morada: Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 PORTO

Os autores deste trabalho, Ana Daniela Martins Almeida nº 100601041, Eugénia Catarina Gonçalves Bastos nº 200500902, Tânia Raquel Silva Gonçalves nº 201106209, estudantes do MICF da Faculdade de Farmácia da Universidade do Porto, declaramos ter atuado com absoluta integridade na elaboração desta monografia. Nesse sentido, confirmamos que NÃO incorremos em plágio (ato pelo qual um indivíduo, mesmo por omissão, assume a autoria de um determinado trabalho intelectual ou partes dele). Mais declaramos que todas as frases que retiramos de trabalhos anteriores pertencentes a outros autores foram referenciadas ou redigidas com novas palavras, tendo neste caso colocado a citação da fonte bibliográfica.

 

Faculdade de Farmácia da Universidade do Porto, 29 de Maio de 2015

Declaração de integridade

Trabalho  realizado no âmbito da disciplina de Toxicologia Mecanística no ano letivo 2014/2015 do Curso de Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Farmácia da Universidade do Porto (FFUP) - Portugal.

 

Este trabalho tem a responsabilidade pedagógica e científica do Prof. Doutor Fernando  Remião do Laboratório de Toxicologia da FFUP

 

http://remiao.wix.com/toxicologia

remiao@ff.up.pt - Prof. Fernando Remião

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